The present study aims to examine the impact of economic complexity on wealth in 48 leading knowledge-producing countries based on the Scimago ranking system during the period 2011–2020. To this end, the research model was estimated using the dynamic panel data approach and the generalized method of moments (GMM) estimator. The findings indicate that economic complexity, along with control variables including market complexity, business complexity, institutions, human capital, research, and infrastructure, has a positive and significant effect on wealth. Accordingly, it is recommended that policymakers and economic decision-makers promote wealth creation and strengthen their international position by diversifying exports of goods and services, improving product quality, enhancing productivity, optimizing resource allocation, and reducing production costs, all of which can be achieved through the integration and application of diverse knowledge.